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Different host-tissue microenvironments select for cancer cells with distinct metastatic traits, which gives rise to organ-specific populations of metastatic cells [14]

43 A number of other animal model studies have also demonstrated that genetic deficiency in negative regulators of the canonical NF-B pathway, such as the deubiquitinases CYLD and A20, promotes colonic inflammation

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Such integrative analyses have revealed correlations between gut microbiota signatures, clinical outcomes, and BA profiles in cancer and related inflammatory conditions (126, 139, 173)